Association of G72/G30 with schizophrenia in the Chinese population
Copyright policy )Association of G72/G30 with schizophrenia in the Chinese population
Recently, the G72 gene was reported to be associated with schizophrenia in the French Canadian and Russian populations. Here, we report the results obtained from the study of six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs1935062, rs778293, and rs3918342), which span an 82-kb region covering the complementary DNA sequences of G72 and G30, in 537 schizophrenia cases and 538 controls of the Han Chinese. In this work, we have identified statistically significant differences in allele distributions of two markers rs3916965 (P = 0.019) and rs2391191 (P = 0.0010), and a highly significant association between haplotype AGAC of the G72/G30 locus (P = 1.7 x 10(-4)) and schizophrenia. Our data provide further evidence that markers of the G72/G30 genes are associated with schizophrenia in a non-Caucasian population.
- Chinese Academy of Sciences China (People's Republic of)
- Shanghai Jiao Tong University China (People's Republic of)
- Center for Life Sciences China (People's Republic of)
Adult, Genetic Markers, Male, China, Genotype, Intracellular Signaling Peptides and Proteins, Proteins, Middle Aged, Polymorphism, Single Nucleotide, Haplotypes, Schizophrenia, Humans, Female, Genetic Predisposition to Disease, RNA, Messenger, Carrier Proteins, Alleles
Adult, Genetic Markers, Male, China, Genotype, Intracellular Signaling Peptides and Proteins, Proteins, Middle Aged, Polymorphism, Single Nucleotide, Haplotypes, Schizophrenia, Humans, Female, Genetic Predisposition to Disease, RNA, Messenger, Carrier Proteins, Alleles
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