Circulating microRNAs as Promising Tumor Biomarkers
Circulating microRNAs as Promising Tumor Biomarkers
microRNAs (miRNAs) are small, nonprotein-coding RNAs that function as posttranscriptional regulators of target genes. miRNAs are involved in multiple cell differentiation, proliferation, and apoptosis processes that are closely related to tumorigenesis. Circulating miRNAs are promising cancer biomarkers under development with great translational potential in personalized medicine. Here, we describe the origin and function of circulating miRNAs and compare the current new high-throughput technology applied to miRNA quantitation. The latest publications on circulating miRNAs were summarized, indicating that miRNAs are potential biomarkers of diagnosis, prognosis, and treatment response of major cancer types including prostate, breast, lung, colorectal, and hematological cancers. We addressed the strengths and limitations of applying circulating miRNAs in clinical laboratory and several issues associated with the accurate measurement of circulating miRNAs.
- The University of Texas System United States
- The University of Texas MD Anderson Cancer Center United States
Male, Lung Neoplasms, High-Throughput Nucleotide Sequencing, Prostatic Neoplasms, Breast Neoplasms, Prognosis, Gene Expression Regulation, Neoplastic, MicroRNAs, Hematologic Neoplasms, Neoplasms, Biomarkers, Tumor, Humans, Female, Colorectal Neoplasms, Oligonucleotide Array Sequence Analysis
Male, Lung Neoplasms, High-Throughput Nucleotide Sequencing, Prostatic Neoplasms, Breast Neoplasms, Prognosis, Gene Expression Regulation, Neoplastic, MicroRNAs, Hematologic Neoplasms, Neoplasms, Biomarkers, Tumor, Humans, Female, Colorectal Neoplasms, Oligonucleotide Array Sequence Analysis
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