• shareshare
  • link
  • cite
  • add
auto_awesome_motion View all 3 versions
Publication . Part of book or chapter of book . 2018

Serotonin receptor imaging by 18F-PET

Thierry Billard; François Liger; Mathieu Verdurand;
Closed Access
Published: 01 Jan 2018
Publisher: HAL CCSD
Country: France

Abstract The serotonergic system plays a key modulatory role in the brain. This system is critical in many drug developments for brain disorders via interactions with the 14 subtypes of 5-HT receptors or through reuptake blockade. Positron emission tomography (PET) is an efficient tool for in vivo studies of physiological and pathological processes. Because of its pertinent radiochemical properties, fluorine-18 is one of the most used radioisotopes in PET imaging. This chapter will propose an overview of the 18F-radioligands targeting serotonin receptors, which have been developed over the last few years. Both radiosyntheses and pharmacological properties of these radiotracers will be described, with a specific emphasis on their potential medical applications.

Subjects by Vocabulary

ACM Computing Classification System: ComputingMilieux_MISCELLANEOUS

Microsoft Academic Graph classification: Serotonergic Receptor 5-HT receptor Pet imaging Reuptake Positron emission tomography medicine.diagnostic_test medicine Blockade business.industry business Neuroscience


[CHIM]Chemical Sciences, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine

Related Organizations