Enhancement of 3H-diazepam binding by SQ 65,396: A novel anti-anxiety agent
Copyright policy )Enhancement of 3H-diazepam binding by SQ 65,396: A novel anti-anxiety agent
SQ 65,396, a clinically active anti-anxiety agent, enhanced the binding of 3H-diazepam at 1.5 nM. This effect was due to an increase in the affinity for the ligand, without a change in the number of 3H-diazepam binding sites. This action of SQ 65,396 may mediate its anti-anxiety effects by affecting the action of an endogenous modulator of the "benzodiazepine receptor." Several other substances and treatments increase the affinity of 3H-diazepam for its receptors by mechanisms which may be related to the effect produced by SQ 65,396.
- American Cyanamid United States
Male, Diazepam, Pyridines, Receptors, Drug, Brain, In Vitro Techniques, Rats, Kinetics, Anti-Anxiety Agents, Animals, Pyrazoles
Male, Diazepam, Pyridines, Receptors, Drug, Brain, In Vitro Techniques, Rats, Kinetics, Anti-Anxiety Agents, Animals, Pyrazoles
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