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The reaction of glyoxal with nucleic acid components

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1973Publisher:Elsevier BVJournal:Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, volume 294, pages 378-384 (issn: 0005-2787,

Authors: E.J. Budowsky; N.E. Broude;

doi: 10.1016/0005-2787(73)90092-0

pmid: 4705992

The reaction of glyoxal with nucleic acid components

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Abstract

Abstract 1. In the reaction of glyoxal with native DNA of T2 phage at temperatures below its T m modified deoxyguanosine residues are formed. 2. Kinetics of the unwinding of T2 phage DNA suggest that the reaction of glyoxal with native DNA results in fixation of the transiently-open regions of the bihelical structure and in further propagation of the defective regions leading to complete denaturation. 3. In contrast to the action of formaldehyde the action of glyoxal leads primarily to the unwinding of G · C-rich regions of DNA.

Related Organizations

Russian Academy of Sciences
Russian Federation

Keywords

Aldehydes, Binding Sites, Guanosine, Chromatography, Paper, Glyoxal, Nucleic Acid Denaturation, Coliphages, Kinetics, DNA, Viral, Spectrophotometry, Ultraviolet

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	22
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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average