Four patients (three women and one man, 30 to 63 years old) developed increased intraocular pressure during graft rejection reactions. The increased intraocular pressure returned to normal in one case after successful treatment of the immune reaction but a second patient required antiglaucoma medication for a short period. Two patients with previous intraocular inflammation or anterior segment changes developed severe glaucoma and required long-term antiglaucoma medication. One patient was a corticosteroid-responder and eventually required filtering surgery.