publication . Article . 2016

Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action

Cushnie, T. P. Tim; O’Driscoll, Noëlle H.; Lamb, Andrew J.;
Open Access
  • Published: 08 Jul 2016
Abstract
Efforts to reduce the global burden of bacterial disease and contend with escalating bacterial resistance are spurring innovation in antibacterial drug and biocide development and related technologies such as photodynamic therapy and photochemical disinfection. Elucidation of the mechanism of action of these new agents and processes can greatly facilitate their development, but it is a complex endeavour. One strategy that has been popular for many years, and which is garnering increasing interest due to recent technological advances in microscopy and a deeper understanding of the molecular events involved, is the examination of treated bacteria for changes to th...
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free text keywords: antibiotic, antiseptic, disinfectant, mode of action, SEM, TEM, Cell Biology, Cellular and Molecular Neuroscience, Pharmacology, Molecular Biology, Molecular Medicine, Biology, DNA Synthesis Inhibitors, Spheroplast, Biochemistry, Antibacterial drug, Ultrastructure, FtsZ, biology.protein, Mode of action, Bacterial disease, Mechanism of action, medicine.symptom, medicine
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