The Uralide orogen, in Central Russia, is the focus of intense geoscientific investigations during recent years. The international research is motivated by some unusual lithospheric features compared with other collisional belts including the preservation of (a) a collisional architecture with an orogenic root and a crustal thickness of 55–58 km, and (b) large volumes of very low-grade and non-metamorphic oceanic crust and island arc rocks in the upper crust of a low–relief mountain belt. The latter cause anomalous gravity highs along the thickened crust and the isostatic equilibrium inside the Uralides lithosphere as well as the overthrust high-metamorphic rocks. The integrated URSEIS '95 seismic experiment provides fundamentally new data revealing the lithospheric architecture of an intact Paleozoic collisional orogen that allows the construction of density models. In the Urals' lithosphere different velocity structures resolved by wide-angle seismic experiments along both the URSEIS '95- and the Troitsk profile. They can be used to constrain lithospheric density models: a first model consists of a deep subducted continental lower crust which has been highly eclogitized at depths of 60–90 km to a density of 3550 kg/m3. The second model shows a slightly eclogitized lower crust underlying the Uralide orogen with a crustal thickness of 60 km. The eclogitized lower crust causes a too-small impedance contrast to the lithospheric mantle resulting in a lack of reflectors in the area of the largest crustal thickness. Both models fit the measured gravity field. Analyzing the isostatic state of the southern Urals' lithosphere, both density models are in isostatic equilibrium.