Molecular cloning of cat interleukin-12
Copyright policy )Molecular cloning of cat interleukin-12
The recently discovered interleukin-12 (IL-12) is a heterodimeric 70000 Mr cytokine composed of a disulphide-bonded 35000 Mr (p35) subunit and a 40000 Mr (p40) subunit. Produced mainly by activated monocytes/macrophages and B cells, it enhances NK/LAK cell cytolytic activity and stimulates cytotoxic T-cell responses and IFN-γ production. It is therefore a key regulatory molecule in T-helper-cell type-1 (Th-1)-driven immune responses that are considered necessary for the elimination of intracellular pathogens.
- Utrecht University Netherlands
Diergeneeskunde, Base Sequence, Molecular Sequence Data, Cats, Animals, Amino Acid Sequence, Cloning, Molecular, Interleukin-12, Sequence Alignment
Diergeneeskunde, Base Sequence, Molecular Sequence Data, Cats, Animals, Amino Acid Sequence, Cloning, Molecular, Interleukin-12, Sequence Alignment
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