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Expression and implication of hypoxia inducible factor-1α in prostate neoplasm

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2004 English Publisher:Springer Science and Business Media LLCJournal:Current Medical Science, volume 24, pages 593-595 (issn: 2096-5230, eissn: 2523-899X,

Authors: Ping Hao; Gu Longjie; Lu Gongcheng; Chen Jiang; Chen Xiaochun; Geng Huaizhen;

doi: 10.1007/bf02911365

pmid: 15791851

Expression and implication of hypoxia inducible factor-1α in prostate neoplasm

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Abstract

To study the expression of hypoxia inducible factor-1alpha (HIF-1alpha) protein in prostate cancer (Pca) and its biological significance, the expression of HIF-1alpha was assayed by means of immunohistochemical technique in 42 prostate cancer, 12 prostatic intraepithelial neoplasm (PIN) and 9 normal prostate tissue (NP) specimens. Western blot was used to examine the expression of HIF-1alpha in prostate cancer cell line (PC-3M) induced by different oxygen tension. HIF-1alpha expression was positive in 33 Pca and 9 PIN specimens, and the positive rate of HIF-1alpha was higher in distant metastasis patients than in patients without metastasis of prostate cancer (P<0.05), while there was no expression of HIF-1alpha in NP. The level of HIF-1alpha in PC-3M significantly increased with the decrease of oxygen tension (P<0.01). Overexpression of HIF-1alpha is the preliminary event of the formation of Pca, which may induce carcinoma into malignant phenotype. Thus it may serve as an early diagnosis marker and the novel target for Pca treatment.

Related Organizations

Union Hospital
China (People's Republic of)
Huazhong University of Science and Technology
China (People's Republic of)
Heze Municipal Hospital
China (People's Republic of)

Keywords

Male, Cell Line, Tumor, Biomarkers, Tumor, Humans, Prostatic Neoplasms, Adenocarcinoma, Hypoxia-Inducible Factor 1, alpha Subunit

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