Effects of collisions with interplanetary particles are investigated. To this purpose, collision probabilities for comets with different orbital elements are computed. It is found that collisions may have a non-negligible effect on the physical evolution of comets. In this connection, it is shown that under certain conditions collisional lifetimes may be shorter than dynamical or vaporization lifetimes. In particular, collisional lifetimes are on average shorter for comets in retrograde orbits than those for direct ones. It is further suggested that catastrophic collisions may contribute to prevent long-period comets in retrograde orbits from reaching short-period orbits by orbital diffusion. Collisions may also produce irregularities of the nucleus brightness by leaving exposed regions of fresh volatile material and may in this way lead to a ‘rejuvenation’ of old dusty short-period comets. Catastrophic collision probabilities are too low to account for the observed comet splittings, so other trigger mechanisms should be at work. However, it is shown that collisional mini-bursts (increases in brightness of one magnitude or so) caused by decimeter-sized bodies may occur rather frequently on short-period comets when they pass through the asteroid belt. The burst observed in comet Tempel-2 at ∼3 AU in December, 1978 could be an example of such collisional mini-bursts. The systematic observation of periodic comets when they pass through the asteroid belt could give valuable information about the spatial density of decimeter and meter-sized bodies. In particular, collisional effects for comet Halley, for which a continuous surveillance is planned, are evaluated.