Spinal cord compression is one of the most devastating complications of cancer. Palliation for this complication is of paramount importance, for survival is frequently prolonged, and the paralytic effects of cord compression can be an overwhelming ordeal for both the patient and the family. Nursing care, physical therapy, rehabilitation, and psychosocial attention are all part of the expanded health care needs of patients with residual neurologic damage from spinal cord compression. The two critical determinants of successful palliation are early clinical recognition of the syndrome and maximum combined modality therapy once the syndrome is diagnosed.