Among postoperative complications associated with liver surgery, such as infections, fluid collections, deep venous thrombosis, bleeding, and bile leak, liver insufficiency/failure is typically the most life-threatening condition. In fact, post-hepatectomy liver failure (PHLF) can be the cause of serious morbidity and mortality after liver resection, especially among patients with fibrosis or cirrhosis of the underlying liver. Several risk factors for PHLF have been described, including patient characteristics, liver quality and volume, as well as intraoperative variables.