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Histone Deacetylases

Name: Histone Deacetylases
Creator: Horn, David
Keywords: EXPRESSION, 0301 basic medicine, 0303 health sciences, ACETYLATION, APICIDIN, Acetylation, PROTEIN DEACETYLASES, CHROMATIN-STRUCTURE, Histone Deacetylases, CELL-CYCLE PROGRESSION

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 12 Sep 2008 United Kingdom English Publisher:Springer New York

Authors: Horn, David;

doi: 10.1007/978-0-387-77570-8_7

pmid: 18365660

Histone Deacetylases

- Summary
- Subjects
- Metrics

Abstract

Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic potential.

Country

United Kingdom

Related Organizations

University of Dundee
United Kingdom
London School of Hygiene & Tropical Medicine
United Kingdom

Keywords

EXPRESSION, ACETYLATION, APICIDIN, Acetylation, PROTEIN DEACETYLASES, CHROMATIN-STRUCTURE, Histone Deacetylases, CELL-CYCLE PROGRESSION, Histone Deacetylase Inhibitors, Histones, TRYPANOSOMA-BRUCEI, Animals, Humans, Trypanosomatina, TRANSCRIPTION, INHIBITORS, PARASITE

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	14
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%