This chapter highlights the recent developments in the metalation of thiazoles and benzothiazoles as well as the reactions of the resulting metalated species (2000 to present). Metalation reactions consist of lithiation (including halogen dance reactions), magnesation, zincation, caldation, boronation, and silylation, while application of the metalated thiazoles focuses on nucleophilic additions and metal-catalyzed cross-coupling reactions (Stille, Negishi, and Suzuki). The power of these metalated reactions is amply demonstrated in the total synthesis of the thiazolyl peptide GE2270A.