There are various applications, both in medical and non-medical image analysis, which require the automatic detection of the line (2D images) or plane (3D) of reflective symmetry of objects. There exist relatively simple methods of finding reflective symmetry when object images are complete (i.e., completely symmetric and perfectly segmented from image “background”). A much harder problem is finding the line or plane of symmetry when the object of interest contains asymmetries, and may not have well defined edges.