RNA Polymerase: Structural Similarities Between Bacterial RNA Polymerase and Eukaryotic RNA Polymerase II

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2000 English Publisher:Elsevier BVJournal:Journal of Molecular Biology, volume 304, pages 687-698 (issn: 0022-2836,

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Authors: R H, Ebright;

doi: 10.1006/jmbi.2000.4309

pmid: 11124018

RNA Polymerase: Structural Similarities Between Bacterial RNA Polymerase and Eukaryotic RNA Polymerase II

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Abstract

Bacterial RNA polymerase and eukaryotic RNA polymerase II exhibit striking structural similarities, including similarities in overall structure, relative positions of subunits, relative positions of functional determinants, and structures and folding topologies of subunits. These structural similarities are paralleled by similarities in mechanisms of interaction with DNA.

Related Organizations

Howard Hughes Medical Institute
United States
Rutgers, The State University of New Jersey
United States

Keywords

Models, Molecular, Binding Sites, Bacteria, Base Sequence, Protein Conformation, DNA, DNA-Directed RNA Polymerases, Protein Subunits, Eukaryotic Cells, Animals, Humans, RNA Polymerase II

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