Hematopoietic Activity Associated with Biglycan-like Proteoglycan

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1993 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 195, pages 1,119-1,126 (issn: 0006-291X,

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Authors: I, Kamo; A, Kikuchi; I, Nonaka; E, Yamada; J, Kondo;

doi: 10.1006/bbrc.1993.2160

pmid: 8373390

Hematopoietic Activity Associated with Biglycan-like Proteoglycan

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Abstract

One of the monocytic cell colony stimulating factors produced by thymic myoid cells, a 100 kDa factor, was purified by reversed phase HPLC and found to be homologous to the secreted form of proteoglycan 1 (biglycan) core protein. This biglycan associated colony stimulating factor did not carry an immunological motif of macrophage colony stimulating factor (M-CSF), but predominantly stimulated the proliferation and differentiation of monocytic lineage cells from bone marrow cells, nonadherent thymic cells and peritoneal exudate cells.

Related Organizations

Mitsubishi
Japan

Keywords

Extracellular Matrix Proteins, Macrophage Colony-Stimulating Factor, T-Lymphocytes, Molecular Sequence Data, Cell Differentiation, Thymus Gland, Chromatography, Ion Exchange, Hematopoietic Stem Cells, Recombinant Proteins, Cell Line, Rats, Colony-Stimulating Factors, Bone Marrow, Biglycan, Animals, Humans, Proteoglycans, Amino Acid Sequence, Cell Division, Chromatography, High Pressure Liquid

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