Position of Cyclization in Cyclic ADP-Ribose

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1993 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 194, pages 1,143-1,147 (issn: 0006-291X,

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Authors: H, Kim; E L, Jacobson; M K, Jacobson;

doi: 10.1006/bbrc.1993.1941

pmid: 8352770

Position of Cyclization in Cyclic ADP-Ribose

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Abstract

Cyclic adenosine diphosphoribose (cADPR) is a putative second messenger of calcium homeostasis synthesized from NAD by cleavage of the nicotinamide-ribose bond and cyclization of the ribose to the adenine ring. In this study, the ultraviolet absorption spectra of cADPR have been studied as a function of pH and compared to other compounds containing an adenine ring with substitutions at known positions. The results support a structure for cADPR in which cyclization is to position 1 of the adenine ring, rather than to N6, as has been previously proposed.

Related Organizations

University of Kentucky
United States

Keywords

Adenosine Diphosphate Ribose, Cyclic ADP-Ribose, Adenosine, Models, Chemical, Adenine, Spectrophotometry, Ultraviolet, Hydrogen-Ion Concentration

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