publication . Article . Other literature type . 2013

Different anesthesia regimes modulate the functional connectivity outcome in mice

Disha Shah; Marleen Verhoye; Elisabeth Jonckers; Rafael Delgado y Palacios; Caroline Guglielmetti; Annemie Van der Linden;
Open Access
  • Published: 29 Oct 2013 Journal: Magnetic Resonance in Medicine, volume 72, issue 4, pages 1,103-1,112 (issn: 0740-3194, Copyright policy)
  • Publisher: Wiley
  • Country: Belgium
Abstract
Purpose The use of resting-state functional MRI (rsfMRI) in preclinical research is expanding progressively, with the majority of resting-state imaging performed in anesthetized animals. Since anesthesia may change the physiology and, in particular, the neuronal activity of an animal considerably, it may also affect rsfMRI findings. Therefore, this study compared rsfMRI data from awake mice with rsfMRI results obtained from mice anesthetized with α-chloralose (120 mg/kg), urethane (2.5 g/kg), or isoflurane (1%). Methods Functional connectivity (FC) was estimated using both independent component analysis (40 components) and ROI-based analysis to zoom in on the ef...
Subjects
free text keywords: Biology, Human medicine, Radiology Nuclear Medicine and imaging, a-chloralose, conscious, mouse, urethane, Premovement neuronal activity, Preclinical research, Connectome, Magnetic resonance imaging, medicine.diagnostic_test, medicine, Functional connectivity, Chemistry, Chloralose, chemistry.chemical_compound, Nerve net, medicine.anatomical_structure, Isoflurane, medicine.drug, Anesthesia
Related Organizations
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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