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Publication . Article . 2002

Fanconi anemia protein complex is a novel target of the IKK signalsome

Tetsuya Otsuki; David B. Young; Dennis T. Sasaki; Matthew P. Pando; Jianwu Li; Anthony M. Manning; Merl F. Hoekstra; +3 Authors
Open Access
Published: 01 Jan 2002 Journal: Journal of Cellular Biochemistry, volume 86, pages 613-623 (issn: 0730-2312, eissn: 1097-4644, Copyright policy )
Publisher: Wiley
Fanconi anemia (FA), a genetic disorder predisposing to aplastic anemia and cancer, is characterized by hypersensitivity to DNA-damaging agents and oxidative stress. Five of the cloned FA proteins (FANCA, FANCC, FANCE, FANCF, FANCG) appear to be involved in a common functional pathway that is required for the monoubiquitination of a sixth gene product, FANCD2. Here, we report that FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2 (IKK2 K > M). When exposed to mitomycin C, cells expressing IKK2 K > M develop a cell cycle abnormality characteristic of FA. Thus, FANCA may function to recruit IKK2, thus providing the cell a means of rapidly responding to stress. J. Cell. Biochem. 86: 613–623, 2002. © 2002 Wiley-Liss, Inc.
Subjects by Vocabulary

Microsoft Academic Graph classification: IκB kinase Fanconi anemia, complementation group C Biology FANCE Cancer research Genetics FANCF Fanconi anemia medicine.disease medicine FANCA FANCD2 FANCG

Medical Subject Headings: hemic and lymphatic diseases congenital, hereditary, and neonatal diseases and abnormalities nutritional and metabolic diseases


Cell Biology, Molecular Biology, Biochemistry