publication . Article . 2007

CYP3A4 and pregnane X receptor humanized mice

Frank J. Gonzalez;
Open Access
  • Published: 23 Aug 2007
Abstract
Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450- and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (BAC) and P1 phage artificial chromosomes (PAC) genomic clones. In some cases, transgenic mice carrying the human genes are bred with null-mice to produce fully humanized mice. Mice expressing human CYP1A1, CYP1A2, CYP2E1, CYP2D6, CYP3A4, and CYP3A7 were generated and characterized. Studies with the CYP3A4-humanized (hCYP3A4) mouse line revealed new information on the physiological...
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free text keywords: Health, Toxicology and Mutagenesis, Toxicology, Molecular Biology, Molecular Medicine, Biochemistry, General Medicine, CYP3A4, Cytochrome P450, biology.protein, biology, Genetically modified mouse, Pregnane X receptor, Pharmacology, In vivo, Drug metabolism, Receptor, Transgene
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