publication . Article . 2014

Acute liver allograft antibody-mediated rejection: An inter-institutional study of significant histopathological features

Jacqueline G. O'Leary; S. Michelle Shiller; Christopher Bellamy; Michael A. Nalesnik; Hugo Kaneku; Linda W. Jennings; Kumiko Isse; Paul I. Terasaki; Goran B. Klintmalm; Anthony J. Demetris;
Open Access
  • Published: 25 Sep 2014 Journal: Liver Transplantation, volume 20, pages 1,244-1,255 (issn: 1527-6465, Copyright policy)
  • Publisher: Wiley
  • Country: United Kingdom
Abstract
<p>Acute antibody-mediated rejection (AMR) occurs in a small minority of sensitized liver transplant recipients. Although histopathologic characteristics have been described, specific features that could be used: a) for a generalizable scoring system; and b) to trigger a more in-depth analysis are needed to screen for this rare but important finding. Toward this goal, we created a training and validation cohort from 3 high volume liver transplant programs of putative acute AMR and control cases that were evaluated blindly by 4 independent transplant pathologists. Evaluations were performed on H&amp;E sections alone without knowledge of either serum DSA results o...
Subjects
free text keywords: Hepatology, Surgery, Transplantation, Scoring system, Antibody mediated rejection, H&E stain, Medicine, business.industry, business, Liver transplantation, medicine.medical_treatment, Human leukocyte antigen, Biopsy, medicine.diagnostic_test, Pathology, medicine.medical_specialty, Isoantibodies, Retrospective cohort study
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