descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1952 English Publisher:Elsevier BVJournal:Journal of the American Pharmaceutical Association (Scientific ed.), volume 41, pages 606-608 (issn: 0095-9553,

Authors: Clara M. Ambrus; Joseph W.E. Harrisson; Julian L. Ambrus; C.E. Moser; Charles A. Leonard;

doi: 10.1002/jps.3030411115

pmid: 12999631

Synergism between Histamine, Antihistamines, and Hypnotic Drugs†

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Abstract

The synergism between antihistamines and the barbiturate Evipal was studied in mice. Similar synergism was found between histamine and barbiturates and between antihistamines and ether. The possible clinical usefulness of these findings is discussed. Thephorin, in mice, shows a synergistic effect with barbiturates or ether similar to that of Benadryl; yet according to clinical reports, Thephorin is rather a cerebral stimulant in humans. It is thus believed that this procedure is not suitable to assay sedative side effects of antihistamines experimentally.

Related Organizations

University of the Sciences
United States

Keywords

Barbiturates, Histamine Antagonists, Histamine H1 Antagonists, Humans, Hypnotics and Sedatives, Histamine

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