Acetaminophen-aluminum hydroxide interaction was investigated in a crossover study using six rabbits. Blood samples were collected at various time intervals for up to 6 hr following the oral administration of acetaminophen alone or in combination with aluminum hydroxide. Aluminum hydroxide at a 40-mg/kg dose did not appear to affect the rate and extent of acetaminophen absorption. The influence of aluminum hydroxide on gastric emptying could be compromised by gastric absorption of acetaminophen, resulting in a negligible effect on the overall bioavailability of acetaminophen.