Effect of Carnitine Analogs on Carnitine Acetyltransferase
Copyright policy )Effect of Carnitine Analogs on Carnitine Acetyltransferase
Carnitine analogs with various substituents on the nitrogen were tested for their effect on carnitine acetyltransferase from rat sperm and pigeon breast. A radiometric assay was used to measure the formation of acetylcarnitine in the presence of other enzymes that competed for acetyl coenzyme A in the sperm preparation. The apparent enzyme inhibition caused by the analogs was explained by the analogs serving as alternative substrates with higher Km and lower Vmax values. The analogs had no effect on whole sperm.
- Stanford University United States
- Eli Lilly (United States) United States
- Virginia Commonwealth University United States
- Virginia Commonwealth University Medical Center United States
Male, Carnitine O-Acetyltransferase, Muscles, Fertilization in Vitro, In Vitro Techniques, Spermatozoa, Kinetics, Mice, Acetyltransferases, Carnitine, Animals, Female, Columbidae
Male, Carnitine O-Acetyltransferase, Muscles, Fertilization in Vitro, In Vitro Techniques, Spermatozoa, Kinetics, Mice, Acetyltransferases, Carnitine, Animals, Female, Columbidae
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