Solubility in Amide–Water Cosolvent Systems II: Cosolvent Excess at Solute Surface

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1979 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 68, pages 1,141-1,143 (issn: 0022-3549,

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Authors: R E, Lindstrom;

doi: 10.1002/jps.2600680922

pmid: 501537

Solubility in Amide–Water Cosolvent Systems II: Cosolvent Excess at Solute Surface

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Abstract

The solubility of methylparaben was determined at 25 degrees in a series of amide-water cosolvent systems. The data were used to demonstrate the possibility of an amide excess at or near the ester solute over that in the bulk solvent. The analysis, stemming from an interfacial tension-solute area solubility model proposed by earlier workers, involved data obtained as a function of amide concentration and as a function of amide alkylation. Both sets of data support the basic contention of the paper.

Related Organizations

University of Connecticut
United States

Keywords

Solubility, Surface Properties, Solvents, Parabens, Water, Amides

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