High-pressure liquid chromatographic procedures are described for clindamycin, clindamycin palmitate, and clindamycin phosphate as bulk drugs and in formulations. All three procedures utilize a C18 reversed-phase chromatographic column with refractive index detection. The mobile phases are hydroalcoholic solutions containing dioctyl sodium sulfosuccinate or disodium ethylenediaminetetraacetate. Separations of related impurities or degradation products also are discussed. The relative standard deviations of the methods range from 0.8 to 1.8%.