
pmid: 4473532
Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl. Tests to date have indicated quite high pharmacological activity by mitragynine pseudoindoxyl. Both metabolites were synthesized to verify structures.
Methyl Ethers, Magnetic Resonance Spectroscopy, Time Factors, Spectrophotometry, Infrared, Hydrogen-Ion Concentration, Secologanin Tryptamine Alkaloids, Mass Spectrometry, Fermentation, Methylmethacrylates, Spectrophotometry, Ultraviolet, Chromatography, Thin Layer, Mitosporic Fungi, Oxidation-Reduction
Methyl Ethers, Magnetic Resonance Spectroscopy, Time Factors, Spectrophotometry, Infrared, Hydrogen-Ion Concentration, Secologanin Tryptamine Alkaloids, Mass Spectrometry, Fermentation, Methylmethacrylates, Spectrophotometry, Ultraviolet, Chromatography, Thin Layer, Mitosporic Fungi, Oxidation-Reduction
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