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5-Fluorouracil and Derivatives in Cancer Chemotherapy: Determination of 5-Fluorouracil in Blood

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1972 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 61, pages 301-303 (issn: 0022-3549,

Authors: J.L. Sutter; John J. Windheuser; E. Auen;

doi: 10.1002/jps.2600610243

pmid: 5059811

5-Fluorouracil and Derivatives in Cancer Chemotherapy: Determination of 5-Fluorouracil in Blood

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Abstract

The current work describes a dialysis technique which separates 5-fluorouracil from interfering blood components and allows for subsequent GC determinations. The parameters affecting the dialysis and GC are presented. The results indicate that 5-fluorouracil is present in the free and bound states in blood, and the method is capable of distinguishing between them.

Related Organizations

University of Wisconsin–Oshkosh
United States

Keywords

Chromatography, Gas, Solubility, Neoplasms, Methods, Humans, Fluorouracil, Hydrogen-Ion Concentration, Dialysis

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	40
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%