Abstract In view of reports in the literature on the anticonvulsant action of various sulfonyl piperazines and of certain substituted 1-sulfonyl-4- β -aminoethylpiperazines as antishock agents, a series of mono- and disulfonyl β -aminoethylpiperazines have been prepared. The compounds were obtained, in most cases, by a modified Schotten-Bauman reaction. The carbobenzyloxy blocking group was employed in the preparation of the monosubstituted compounds and was removed by catalytic hydrogenation without cleavage of the sulfonyl group.