AbstractThe journal Electrophoresis has greatly influenced my approaches to biomolecular affinity studies. The methods that I have chosen as my main tools to study interacting biomolecules – native gel and later capillary zone electrophoresis – have been the topic of numerous articles in Electrophoresis. Below, the role of the journal in the development and dissimination of these techniques and applications reviewed. Many exhaustive reviews on affinity electrophoresis and affinity CE have been published in the last few years and are not in any way replaced by the present deliberations that are focused on papers published by the journal.