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Publication . Article . 2021

The genomics of heart failure: design and rationale of the HERMES consortium

design and rationale of the HERMES consortium
R. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; +159 Authors
Open Access
English
Abstract

Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748

Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050

Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063

Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317

Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077

Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927

Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173

Funder: British Heart Foundation Cardiovascular Biomedicine

Funder: Swedish National Health Service

Subjects by Vocabulary

Microsoft Academic Graph classification: Genetic model Epidemiology medicine.medical_specialty medicine Cardiomyopathy medicine.disease Disease Genotyping Allele frequency Internal medicine business.industry business Odds ratio Heart failure

Subjects

Heart failure, Cardiomyopathy, Genetics, Biomarkers, Association studies, WIDE ASSOCIATION, AFRICAN ANCESTRY, AGING RESEARCH, EPIDEMIOLOGY, METAANALYSIS, CLASSIFICATION, REPLICATION, COHORTS, ADULTS, RISK, Cardiology and Cardiovascular Medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Study Design, Study Designs, Heart failure, Cardiomyopathy, Genetics, Biomarkers, Association studies, Study Design, Study Designs, Cardiac and Cardiovascular Systems, Kardiologi, Regeneron Genetics Center, Diseases of the circulatory (Cardiovascular) system, RC666-701, Regeneron Genetics Center, Aged, 80 and over, Female, Genome-Wide Association Study, Genomics, Heart Failure/genetics, Humans, Male, Middle Aged, Prognosis, FOS: Biological sciences, Aged, 80 and over

Funded by
EC| inHForm
Project
inHForm
Integrative omics of heart failure to inform discovery of novel drug targets and clinical biomarkers
  • Funder: European Commission (EC)
  • Project Code: 679242
  • Funding stream: H2020 | ERC | ERC-STG
,
EC| BigData Heart
Project
BigData Heart
Big Data 4 Better Hearts - Sofia ref.: 116074
  • Funder: European Commission (EC)
  • Project Code: 116074
  • Funding stream: H2020 | IMI2-RIA
Validated by funder
,
EC| inHForm
Project
inHForm
Integrative omics of heart failure to inform discovery of novel drug targets and clinical biomarkers
  • Funder: European Commission (EC)
  • Project Code: 679242
  • Funding stream: H2020 | ERC | ERC-STG
,
EC| BigData Heart
Project
BigData Heart
Big Data 4 Better Hearts - Sofia ref.: 116074
  • Funder: European Commission (EC)
  • Project Code: 116074
  • Funding stream: H2020 | IMI2-RIA
Validated by funder
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Article . 2021
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