Tetrazine‐Responsive Self‐immolative Linkers
Copyright policy )Tetrazine‐Responsive Self‐immolative Linkers
AbstractMolecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.
- University of Strathclyde United Kingdom
- University of Edinburgh United Kingdom
Drug Carriers, Cycloaddition Reaction, 610, Apoptosis, 540, Polyethylene Glycols, Chemistry, Drug Liberation, Heterocyclic Compounds, 1-Ring, HEK293 Cells, Doxorubicin, Cell Line, Tumor, Humans, Nanoparticles, QD
Drug Carriers, Cycloaddition Reaction, 610, Apoptosis, 540, Polyethylene Glycols, Chemistry, Drug Liberation, Heterocyclic Compounds, 1-Ring, HEK293 Cells, Doxorubicin, Cell Line, Tumor, Humans, Nanoparticles, QD
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