Biosynthesis with Fluorine

descriptionPublicationkeyboard_double_arrow_right Article 06 Feb 2014 English Publisher:WileyJournal:ChemBioChem, volume 15, pages 495-497 (issn: 1439-4227, eissn: 1439-7633,

Copyright policy )

Authors: Klopries, Stephan; Koopmans, Kyra R. M.; Sánchez-García, Elsa; Schulz, Frank;

doi: 10.1002/cbic.201300750

pmid: 24504732

handle: 11858/00-001M-0000-0018-B24A-A

Biosynthesis with Fluorine

- Summary
- Subjects
- Metrics

Abstract

No longer in-F-able: fluorine building blocks can be used in polyketide biosynthesis. This represents a more flexible approach to organofluorines than the traditional use of fluorinated starter units in multistep organic syntheses, and will hopefully increase the number of compounds available for drug development.

Related Organizations

Ruhr University Bochum
Germany
Max Planck Society
Germany
Max Planck Institute for Coal Research
Germany
Bochum University of Applied Sciences Health Campus
Germany

Keywords

Biological Products, Halogenation, Polyketides, Biocatalysis, Coenzyme A, Fluorine, Biologie, Polyketide Synthases, Malonates

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average