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Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture

descriptionPublicationkeyboard_double_arrow_right Article 03 Jun 2015 Serbia Publisher:WileyJournal:Advanced Healthcare Materials, volume 4, pages 1,628-1,633 (issn: 2192-2640, eissn: 2192-2659,

Copyright policy )Funded by:NSF | Materials Research Scienc..., NIH | Regulation and Function o..., NIH | Building the Hematopoieti... +1 projects

Authors: Raluca Ostafe; Raluca Ostafe; David A. Weitz; Radivoje Prodanovic; Radivoje Prodanovic; Stefanie Utech; Angelo S. Mao; +2 Authors

doi: 10.1002/adhm.201500021

pmid: 26039892

pmc: PMC4529809

Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture

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Abstract

Monodisperse alginate microgels (10-50 μm) are created via droplet-based microfluidics by a novel crosslinking procedure. Ionic crosslinking of alginate is induced by release of chelated calcium ions. The process separates droplet formation and gelation reaction enabling excellent control over size and homogeneity under mild reaction conditions. Living mesenchymal stem cells are encapsulated and cultured in the generated 3D microenvironments.

Country

Serbia

Related Organizations

RWTH Aachen University
Germany
University of Belgrade
Serbia
Harvard University
United States
University of Belgrade, Faculty of Chemistry
Serbia
Wyss Institute for Biologically Inspired Engineering
United States

Keywords

Alginates, Hexuronic Acids, microfluidics, Cell Culture Techniques, Microfluidic Analytical Techniques, Microspheres, Calcium Carbonate, microgels, Glucuronic Acid, alginate, cells, encapsulation, Nanoparticles, Gels

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Supplementary data for article: Utech, S.; Prodanovic, R.; Mao, A. S.; Ostafe, R.; Mooney, D. J.; Weitz, D. A. Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture. Advanced Healthcare Materials 2015, 4 (11), 1628–1633. https://doi.org/10.1002/adhm.201500021
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