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Advanced Healthcare Materials
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Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture

Authors: Stefanie Utech; Radivoje Prodanovic; Angelo S. Mao; Raluca Ostafe; David J. Mooney; David A. Weitz;

Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture

Abstract

Monodisperse alginate microgels (10–50 μm) are created via droplet‐based microfluidics by a novel crosslinking procedure. Ionic crosslinking of alginate is induced by release of chelated calcium ions. The process separates droplet formation and gelation reaction enabling excellent control over size and homogeneity under mild reaction conditions. Living mesenchymal stem cells are encapsulated and cultured in the generated 3D microenvironments.

This is the peer-reviewed version of the article: Utech, S., Prodanovic, R., Mao, A.S., Ostafe, R., Mooney, D.J., Weitz, D.A., 2015. Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture. Advanced Healthcare Materials 4, 1628–1633. [https://doi.org/10.1002/adhm.201500021]

Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3383]

Country
Serbia
Subjects by Vocabulary

Microsoft Academic Graph classification: Microfluidics Dispersity Nanoparticle Ionic bonding Nanotechnology 3D cell culture chemistry.chemical_compound Cell encapsulation Chemistry Glucuronic acid Chemical engineering Cell culture

Keywords

Alginates, microfluidics, Cell Culture Techniques, Biomedical Engineering, Pharmaceutical Science, Article, Calcium Carbonate, microgels, Biomaterials, Glucuronic Acid, alginate, Hexuronic Acids, Microfluidic Analytical Techniques, Microspheres, cells, encapsulation, Nanoparticles, Gels

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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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impulse
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