Preface BASIC ELECTROMAGNETIC THEORY OF SERS Introduction Plasmon Resonances and Field Enhancements Field Enhancement Distribution and Localization Electromagnetic Model for the SERS and Fluorescence Enhancement Factors The Magnitude of the SERS Enhancement Factor in Typical Cases Conclusions NANOPARTICLE SERS SUBSTRATES Introduction Preparation and Stability of Metal Nanoparticle Colloidal SERS Substrates Characterization of Nanoparticle-Based SERS Substrates Nanoparticles on the Unfunctionalized Solid Surface as SERS Substrates Conclusion and Outlook QUANTITATIVE SERS METHODS Introduction SERS Media Stability and Shelf Life Reproducibility and Internal Standards Selectivity Conclusion SINGLE-MOLECULE- AND TRACE DETECTION BY SERS Introduction Experiments and Results Conclusions DETECTION OF PERSISTENT ORGANIC POLLUTANTS BY USING SERS SENSORS BASED ON ORGANICALLY FUNCTIONALIZED Ag NANOPARTICLES Introduction Inclusion Hosts Contact Hosts Occlusion Hosts Conclusions SERS AND PHARMACEUTICALS Introduction SERS of Antipyretics and Analgesics SERS of Antimalarials SERS of Anticarcinogenics andf Antimutagenics Concluding Remarks SERS AND SEPARATION SCIENCE Introduction SERS and Capillary Electrophoresis (CE) SERS and Liquid Chromatography (LC) SERS and Gas Chromatography (GC) SERS and Thin Layer Chromatography (TLC) Other Separation Methods Conclusions SERS AND MICROFLUIDICS Introduction Lab-on-a-Chip Technology Microfluidic Platforms and Application for SERS Summary ELECTROCHEMICAL SERS AND ITS APPLICATION IN ANALYTICAL, BIOPHYSICAL AND LIFE SCIENCE Electrochemical Surface-Enhanced Raman Spectroscopy Features of Electrochemical Surface-Enhanced Raman Spectroscopy Experimental Techniques of EC-SERS Applications of EC-SERS Perspectives ELECTRON TRANSFER OF PROTEINS AT MEMBRANE MODELS Introduction Model Membranes and Membrane Models Methods for Probing Electron Transfer Processes of Cytochrome c at Coated Electrodes The Unusual Distance Dependence of the Interfacial Electron Transfer Process Electron Transfer and Protein Orientational Dynamics Electric Field Effects on the Electron Transfer Dynamics Electron Transfer and Protein Structural Changes Overall Description of the Mechanism and Dynamics of the Interfacial Processes Interfacial Electric Fields and the Biological Functions of Cytochrome c QUANTITATIVE DNA ANALYSIS USING SURFACE-ENHANCED RESONANCE RAMAN SCATTERING Introduction SERRS Surfaces Raman Reporters SERRS DNA Probes Sensitivity Multiplexing Assays Conclusion SERS MICROSCOPY: NANOPARTICLE PROBES AND BIOMEDICAL APPLICATIONS Introduction SERS Nanoparticle Probes Biomedical Applications of SERS Microscopy Summary and Outlook 1-P AND 2-P EXCITED SERS AS INTRACELLULAR PROBE From Tags to Probes: Challenges in Intracellular Probing Probing of Intracellular Parameters Surface-Enhanced Hyper Raman Scattering and Its Potential in Studies of Cells SURFACE- AND TIP-ENHANCEMENT CARS Introduction CARS: Coherent Anti-Stokes Raman Scattering Local Enhancement of CARS by Metallic Nanostructures Surface-Enhanced CARS Tip-Enhanced CARS