Recent medical literature contains the records of three patients, all negroes, or negroes with an admixture of Caucasian blood, in whom severe anemia, characterized by certain peculiar morphologic alterations of the red blood cells, was present. The first case was reported by Herrick.1Washburn2published the records of a patient whose blood showed similar changes, and Cook and Meyer3reported the third example of this rare type of anemia. REPORT OF CASE The following record is presented in some detail on account of the rarity of the disease: History. —C. P., a negro, aged 21, was admitted to the Johns Hopkins Hospital, March 15, 1915, complaining of general weakness. The family history was fragmentary, and no evidence was adduced to indicate that any other member of the family had suffered from symptoms similar to his. The patient was born in Virginia and had never been farther than