To the Editor.— Your journal has recently presented two publications and one editorial concerning the "puzzling" jaundice seen after the administration of oxyphenisatin acetate, which seem to have taken the cause-effect relationship for granted ( 211 :83-85, 86-90,1970). This cathartic has been used much more in Europe than in the United States, and as far as I know no complications have previously been described. The discrepancies between the findings in these cases and the lack of similar European cases suggests itself. The drug used in all six cases was not a pure one consisting of the single constituent, oxyphenisatin, but a mixture of this substance with sodium methyl cellulose and dioctyl sodium sulfosuccinate. Of these two compounds, methyl cellulose is surely innocent. But what do we know about dioctyl sodium sulfosuccinate? Most textbooks describe this only as a wetting agent, which is not absorbed from the intestinal tract. I do not