TAYBI described a case of "generalized skeletal dysplasia with multiple anomalies" in 1962 which did not fit any previously described disease complex. 1 This paper will present three male siblings seen at the University of Minnesota Hospitals with the same spectrum of anomalies. The patients were referred because of slow progress in school, poor speech development, and probable deafness. The most striking features of the syndrome seemed to be deafness, cleft palate, and digital anomalies, and it was therefore suggested by Dudding et al (oral communication, 1966) that this be called the oto-palato-digital syndrome. Report of Cases Case1.—An 8-year-old boy was admitted to University Hospitals in April 1965, because of poor reading skill and possible deafness. The product of a full-term uncomplicated pregnancy and delivery, he weighed 2.8 kg (6 lb 4 oz) and measured 48.3 cm (19 inches) in length at birth. A cleft soft palate was noted