As a result of many clinical and experimental investigations, current opinion regards epinephrine as producing little if any effect when administrated orally. Sollmann1states that "it is entirely ineffective by oral administration" and that "the blood pressure response is practically absent" when given by mouth. In "Useful Drugs"2it is stated that, "when given by mouth, it produces no evident effect on the general circulation." Cushny3states that "when given by mouth, it has no effect on the blood pressure or heart." According to an article in the "Pharmacology of Useful Drugs,"4"epinephrine is one of the few alkaloids in the materia medica which are not absorbed from the gastrointestinal canal with such rapidity as to induce any appreciable effect." In the recent series of articles on glandular therapy inThe Journal of the American Medical Association, it was stated,5regarding epinephrine, that "when the drug is administered by mouth,