publication . Article . 2013

Self-assembled multivalent RGD-peptide arrays – morphological control and integrin binding

Welsh, Daniel J.; Posocco, Paola; Pricl, Sabrina; Smith, David K.;
Restricted
  • Published: 01 Jan 2013 Journal: Organic & Biomolecular Chemistry, volume 11, page 3,177 (issn: 1477-0520, eissn: 1477-0539, Copyright policy)
  • Publisher: Royal Society of Chemistry (RSC)
Abstract
We report the synthesis of four different RGD peptide derivatives which spontaneously self-assemble into nanoscale architectures. Depending on the information programmed into the molecular-scale building blocks by organic synthesis, these compounds assemble into different nanoscale morphologies. This process can be fully understood using multiscale modelling which provides predictive insight into subtle differences, such as whether the compounds form spherical micelles, rod-like cylinders or tubular assemblies, and predicts experimentally observed critical aggregation concentrations (CACs). We then probe the multivalent binding of these assemblies to integrin pr...
Subjects
free text keywords: Physical and Theoretical Chemistry, Organic Chemistry, Biochemistry, Organic synthesis, chemistry.chemical_compound, chemistry, Combinatorial chemistry, Ligand binding assay, Self-assembly, Integrin, biology.protein, biology, Micelle, RGD peptide, Nanoscale morphology, Ligand
Related Organizations
Funded by
EC| HPC-EUROPA2
Project
HPC-EUROPA2
Pan-European Research infrastructure on High Performance Computing for 21st century Science
  • Funder: European Commission (EC)
  • Project Code: 228398
  • Funding stream: FP7 | SP4 | INFRA
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2013

Self-assembled multivalent RGD-peptide arrays – morphological control and integrin binding

Welsh, Daniel J.; Posocco, Paola; Pricl, Sabrina; Smith, David K.;