publication . Article . 2017

FAST DETECTION OF ACETYLSALICYLIC ACID BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY(LC-MSMS)

Abusoglu, Sedat; Unlu, Ali; Sivrikaya, Abdullah;
Open Access
  • Published: 01 Nov 2017
  • Publisher: Engin TUTKUN
Abstract
ObjectivesAcetylsalicylic acid (ASA) is themost widely used as an analgesic, anti-inflammatory and antipyretic drug, andalso used to inhibit cyclooxygenase dependent platelet aggregation.   The aimof this study was to develop a simple, fast and accurate tandem mass method fordetermination and quantification of ASA.  MethodsChromatographic seperation was performedusing an Shimadzu LC-20-AD (Kyoto, Japan) coupledwith a ABSCIEX API 3200 triple quadrupole massspectrometer(USA) equipped with an electrospray ion source (ESI) operating in negative mode. ResultsIntraassay CV values for acetylsalicylicacid were 8% and 6% for 0.8 and 100...
Subjects
free text keywords: FAST DETECTION OF ACETYLSALICYLIC ACID BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY(LC-MSMS)
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publication . Article . 2017

FAST DETECTION OF ACETYLSALICYLIC ACID BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY(LC-MSMS)

Abusoglu, Sedat; Unlu, Ali; Sivrikaya, Abdullah;