Effect of Subclinical Hypothyroidism on the Mean Platelet Volume of Pregnant Women

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Sari, Oktay ; Tanoglu, Alpaslan ; Mahmutoglu, Onur ; Aydogan, Umit ; Beyazit, Fatma ; Akpak, Yasam Kemal ; Keskin, Ugur (2016)
  • Publisher: Inonu University
  • Journal: Cİlt: 5 Sayı: 1 (issn: 2147-0634, eissn: 2147-0634)
  • Subject: Mean platelet volume, subclinical hypothyroidism, erytocyte parameters, platelet
    mesheuropmc: endocrine system | reproductive and urinary physiology | endocrine system diseases | hormones, hormone substitutes, and hormone antagonists

Subclinical hypothyroidism (SH) is a frequently seen clinical disorder, which needs to be managed strictly in the pregnant population. SH is closely related with newborn complications and also suggested to be risk factor for cardiovascular events. Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk marker for cardiovascular events. The aim of this study was to evaluate how MPV values and other hematological parameters are influenced in pregnants with subclinical hypothyroidism. A total of 70 subclinical hypothyroidic pregnants and 40 euthyroid pregnant controls were enrolled in our study. Age, body mass index (BMI), erythrocyte and platelet parameters were all evaluated. Erytocyte parameters and thrombocyte parameters, including MPV, were not statistically significantly different between pregnants with SH and healthy pregnants (p > 0.05). Mean free T3 and TSH levels of subclinical hypothyroidic pregnants were statistically significantly different from healthy pregnant (p=0.04 and p < 0.01 respectively).Our results suggest that pregnants with subclinical hypothyroidism do not tend to have increased platelet activation, in other words platelet parameters are not different in pregnants with subclinical hypothyroidism in comparison with healthy pregnants
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