publication . Article . 2009

RNA İNTERFERANS (RNAİ)

GÜNDOĞDU, Ramazan; ÇELİK, Venhar;
Open Access
  • Published: 01 Feb 2009
  • Publisher: Erciyes Üniversitesi
Abstract
RNA interference is a post-transcriptional gene silencing process during which endogenous complementary messenger RNA is destroyed upon introduction of the corresponding double-stranded RNA into the cell. The initation of RNA interference occurs with the processing of double-stranded RNA into small interfering RNAs (siRNAs), by an RNase III enzyme called Dicer. These siRNAs are then incorporated into the RNA-Induced Silencing Complex (RISC), a multiprotein-RNA nuclease complex. RISC uses these siRNAs to find complementary mRNA and endonucleolytically cleave target mRNA. Consequently, the reduction of specific mRNAs leads to the reduction of the corresponding pro...
Subjects
free text keywords: RNA İnterferans, RNAi, siRNA, Gen baskılama
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