publication . Article . 2017

Axolotl cells and tissues enhances cutaneous wound healing in mice

Demircan T.; Keskin I.; Gunal Y.; Ilhan A.E.; Kolbasi B.; Ozturk G.;
Open Access
  • Published: 03 Jul 2017
  • Publisher: Ondokuz Mayıs Üniversitesi
  • Country: Turkey
Abstract
Adult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar tissue formation. However, unlike mammals, adult salamanders repair the wounds by regeneration compared to scarring. To elucidate the healing capability of a salamander, Axolotl, in a different species, here we addressed this question by treating the wounds in mice with Axolotl cells or tissues. Excisional lesions were created on each mouse, and animals in different groups treated by; a-) Axolotl blastema tissue, b-) Axolotl tail tissue, c-) Axol...
Subjects
free text keywords: Axolotl,cutaneous wound healing; immune-modulation; regeneration, Tıbbi Araştırmalar Deneysel, Axolotl, Cutaneous Wound Healing, Immune-Modulation, Regeneration
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publication . Article . 2017

Axolotl cells and tissues enhances cutaneous wound healing in mice

Demircan T.; Keskin I.; Gunal Y.; Ilhan A.E.; Kolbasi B.; Ozturk G.;