Mutagenicity of 1-Ethyl-2,4,5-triphenyl-1H-imidazole and Six Derivatives in Salmonella typhimurium

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KORKMAZ, Ferhan ; Korkmaz, Ferhan ; MERCANGOZ, Ayse (2010)
  • Publisher: Gazi University
  • Journal: (issn: 2147-1762)
  • Subject: 1-Ethyl-2,4,5-triphenyl-1H-imidazole, Ames/Salmonella/Microsome assay, mutagenicity, predrug.

 Newly synthesized 1-Ethyl-2,4,5-triphenyl-1H-imidazole and its six derivatives were tested by Ames assay. In order to reveal the mutagenic activities of the compounds, two different mutant strains of Salmonella typhimurium (TA98 and TA100) were used in an Ames assay with/without S9 microsomal fraction from rat liver. It was found that the compounds have no mutagenic activities.                  Key Words: 1-Ethyl-2,4,5-triphenyl-1H-imidazole,                                 Ames/Salmonella/Microsome assay, mutagenicity,                                  predrug.       
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