publication . Article . Other literature type . 2012

Brain lactate metabolism in humans with subarachnoid hemorrhage

Mauro Oddo; Joshua M. Levine; Suzanne Frangos; Eileen Maloney-Wilensky; Emmanuel Carrera; Roy Thomas Daniel; Marc Levivier; Pierre J. Magistretti; Peter D. LeRoux;
Open Access English
  • Published: 01 Jan 2012
  • Country: Switzerland
Background and Purpose— Lactate is central for the regulation of brain metabolism and is an alternative substrate to glucose after injury. Brain lactate metabolism in patients with subarachnoid hemorrhage has not been fully elucidated. Methods— Thirty-one subarachnoid hemorrhage patients monitored with cerebral microdialysis (CMD) and brain oxygen (PbtO2) were studied. Samples with elevated CMD lactate (>4 mmol/L) were matched to PbtO2 and CMD pyruvate and categorized as hypoxic (PbtO2 119 μmol/L) versus nonhyperglycolytic. Results— Median per patient samples with elevated CMD lactate was 54% (interquartile range, 11%–80%). Lactate elevations were more often att...
Persistent Identifiers
free text keywords: Adult, Brain/metabolism, Female, Humans, Lactates/metabolism, Male, Middle Aged, Oxygen/metabolism, Prognosis, Retrospective Studies, Subarachnoid Hemorrhage/diagnosis/metabolism/mortality, Survival Rate, Hypoxia (medical), medicine.symptom, medicine, Subarachnoid hemorrhage, medicine.disease, business.industry, business, Odds ratio, Lactate metabolism, Interquartile range, Cardiology, medicine.medical_specialty, Modified Rankin Scale, Anesthesia, Metabolism, Human brain, medicine.anatomical_structure, Internal medicine
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