publication . Article . Other literature type . 2012

brain lactate metabolism in humans with subarachnoid hemorrhage

Oddo, M.; Levine, J. M.; Frangos, S.; Maloney-Wilensky, E.; Carrera, E.; Daniel, R. T.; Levivier, M.; Magistretti, P. J.; Leroux, P. D.;
Open Access
  • Published: 01 May 2012 Journal: Stroke, volume 43, pages 1,418-1,421 (issn: 0039-2499, eissn: 1524-4628, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
  • Country: Switzerland
Abstract
Background and Purpose— Lactate is central for the regulation of brain metabolism and is an alternative substrate to glucose after injury. Brain lactate metabolism in patients with subarachnoid hemorrhage has not been fully elucidated. Methods— Thirty-one subarachnoid hemorrhage patients monitored with cerebral microdialysis (CMD) and brain oxygen (PbtO2) were studied. Samples with elevated CMD lactate (>4 mmol/L) were matched to PbtO2 and CMD pyruvate and categorized as hypoxic (PbtO2 119 μmol/L) versus nonhyperglycolytic. Results— Median per patient samples with elevated CMD lactate was 54% (interquartile range, 11%–80%). Lactate elevations were more often att...
Subjects
free text keywords: Interquartile range, Modified Rankin Scale, Odds ratio, Subarachnoid hemorrhage, medicine.disease, medicine, Metabolism, Diabetes mellitus, business.industry, business, Physical therapy, medicine.medical_specialty, Internal medicine, Anesthesia, Cardiology, Hypoxia (medical), medicine.symptom, Human brain, medicine.anatomical_structure
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publication . Article . Other literature type . 2012

brain lactate metabolism in humans with subarachnoid hemorrhage

Oddo, M.; Levine, J. M.; Frangos, S.; Maloney-Wilensky, E.; Carrera, E.; Daniel, R. T.; Levivier, M.; Magistretti, P. J.; Leroux, P. D.;