publication . Article . 2013

Impact of HLA Diversity on Donor Selection in Organ and Stem Cell Transplantation

Tiercy Jean-Marie; Claas Frans;
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  • Published: 01 Jan 2013 Journal: Human Heredity, volume 76, pages 178-186 (issn: 0001-5652, eissn: 1423-0062, Copyright policy)
  • Publisher: S. Karger AG
Abstract
The human major histocompatibility complex is a multigene system encoding polymorphic human leucocyte antigens (HLA) that present peptides derived from pathogens to the immune system. The high diversity of HLA alleles and haplotypes in the worldwide populations represents a major barrier to organ and allogeneic hematopoietic stem cell transplantation, because HLA incompatibilities are efficiently recognized by T and B lymphocytes. In organ transplantation, pre-transplant anti-HLA antibodies need to be taken into account for organ allocation. Although HLA-incompatible transplants can be performed thanks to immunosuppressive drugs, the de novo production of anti-H...
Subjects
free text keywords: Genetics(clinical), Genetics
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