publication . Article . 2008

EMMPRIN mediates β-adrenergic receptor-stimulated matrix metalloproteinase activity in cardiac myocytes

Siwik Deborah A; Kuster Gabriela M; Brahmbhatt Jamin V; Zaidi Zaheer; Malik Julia; Ooi Henry; Ghorayeb Ghassan;
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  • Published: 01 Jan 2008 Journal: Journal of Molecular and Cellular Cardiology, volume 44, pages 210-217 (issn: 0022-2828, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Extracellular matrix metalloproteinase inducer (EMMPRIN) expression is increased in myocardium from patients with dilated cardiomyopathy and animal models of heart failure. However little is known about the regulated expression or functional role of EMMPRIN in the myocardium. In rat cardiac cells EMMPRIN is expressed on myocytes but not endothelial cells or fibroblasts. Therefore we tested the hypothesis that EMMPRIN expression regulates matrix metalloproteinase (MMP) activity in rat ventricular myocytes in vitro. In adult rat ventricular myocytes (ARVM) beta adrenergic receptor (betaAR) stimulation and H(2)O(2) (24 h) each increased EMMPRIN expression as assess...
Subjects
free text keywords: Molecular Biology, Cardiology and Cardiovascular Medicine, Stimulation, Adrenergic receptor, Receptor, Cell biology, Matrix metalloproteinase, Metalloproteinase, Superoxide dismutase, biology.protein, biology, MMP2, Myocyte, Endocrinology, medicine.medical_specialty, medicine, Cardiology, Internal medicine
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publication . Article . 2008

EMMPRIN mediates β-adrenergic receptor-stimulated matrix metalloproteinase activity in cardiac myocytes

Siwik Deborah A; Kuster Gabriela M; Brahmbhatt Jamin V; Zaidi Zaheer; Malik Julia; Ooi Henry; Ghorayeb Ghassan;